@article{5a4f394bab8e4da09238f3f1e2d98551,
title = "Live cell measurements of interaction forces and binding kinetics between Discoidin Domain Receptor 1 (DDR1) and collagen I with atomic force microscopy",
abstract = " Background Discoidin Domain Receptors (DDRs) are membrane-tethered proteins of the receptor tyrosine kinase family, which signal in response to collagen. DDR expression is associated with human diseases, including fibrosis and cancer. The role of DDRs in human pathogenesis is mediated by dysregulated receptor function in response to the collagenous milieu. Thus, understanding DDR-collagen interactions is important for developing novel therapeutic strategies against DDRs.",
author = "Hoffmann, {Peter M.} and Anwesha Sarka and Anjum Sohail and Jiayin Dong and Marco Prunotto and Kazuhiko Shinki and Rafael Fridman",
note = "The new approach is applicable to other receptor-ligand systems and allows the determination of critical parameters at the single cell/single molecule level - in particular, the direct determination of kinetic and density differences of receptors in different cell types. This capability should prove ...",
year = "2019",
doi = "10.1016/j.bbagen.2019.07.011",
language = "American English",
journal = "BBA-General Subjects",
issn = "1872-8006",
}